Stem cells and Kidney disease

Kidney failure is an irreversible condition that affects over hundreds of thousands of Americans and causes a large number of deaths every year. While there are many causes of kidney failure, the treatment plan is similar. Patients need to undergo weekly dialysis at huge costs while waiting in a long transplantlist for a donor. Fortunately, advances in regenerative medicine have led to promising treatment for kidney disease and failure.

Healthy kidneys effectively filter waste and excess fluids from the body. But several causes can lead to kidney damage, causing excess fluids, waste, and electrolytes to build up, leading to a wide range of negative effects in the body. The kidneys only have a limited regenerative ability of their own, and eventually, the damage starts affectingother organs too. As a result, the patient that becomes dependent on external dialysis, and gradually, whole organ transplant. About a half of all kidney failure cases are caused by diabetes.

Stem cell therapy for kidney disease

Stem cells have unique anti-inflammatory properties. Stem cell therapy can reduce levels of chronic inflammation within the body to allow healing to occur. In patients of Kidney Disease, the levels of inflammation are high in the body. Reducing inflammation markers to normal levels, can allow the tissues to regenerate and restore normal function.

Stem cell therapy for kidney failure

Studies are underway to find a method to supplement the cells in the kidneys that are instrumental intissue and organ regeneration.

Harvard Stem Cell Institute researchers have recently identified specific mesenchymal stem cells that can allow and accelerate kidney healing. These stem cells can be transplanted into the body to stimulate the natural repair and regeneration of damaged kidney tissue and decrease inflammation. Stem cells have already been used in conjunction with organ transplants to eliminate the need for a lifetime of immunosuppressant drugs. 

Can stem cell therapy cure kidney disease?

Kidneys are complicated organs that provide vital filtration functions within the body and kidneydisease is challenging to treat. Currently, only general stem cell therapy is available to patients to treat these issues.Scientists have yet to isolate the specific cells responsible for kidney repair and regeneration to the extent that failure is reversed.

A reasonably expected outcome of stem cell therapy in kidney disease patients would be significant reduction in inflammatory markers,as compared to pre-treatment levels and an improvement in kidney function. This would not be sufficient to take away the need for dialysis after one therapy, but it is likely to reduce the frequency of dialysis.

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stemcelldr Joined: June 20th, 2018